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KMID : 0861020230380010045
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Korea Journal of Herbology
2023 Volume.38 No. 1 p.45 ~ p.53
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Prediction of functional molecular machanism of Astragalus membranaceus on obesity via network pharmacology analysis
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Kim Mi-Hye
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Abstract
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Objectives : Network pharmacology-based research is one of useful tool to predict the possible efficacy and molecular mechanisms of natural materials with multi compounds-multi targeting effects. In this study, we investigated the functional underlying mechanisms of Astragalus membranaceus Bunge (AM) on its anti-obesity effects using a network pharmacology analysis.
Methods : The constituents of AM were collected from public databases and its target genes were gathered from PubChem database. The target genes of AM were compared with the gene set of obesity to find the correlation. Then, the network was constructed by Cytoscape 3.9.1. and functional enrichment analysis was conducted to predict the most relevant pathway of AM.
Results : The result showed that AM network contained the 707 nodes and 6867 edges, and 525 intersecting genes were exhibited between AM and obesity gene set, indicating that high correlation with the effects of AM on obesity.
Based on GO biological process and KEGG Pathway, ‘Response to lipid’, ‘Cellular response to lipid’, ‘Lipid metabolic process’, ‘Regulation of chemokine production’, ‘Regulation of lipase activity’, ‘Chemokine signaling pathway’, ‘Regulation of lipolysis in adipocytes’ and ‘PPAR signaling pathway’ were predicted as functional pathways of AM on obesity.
Conclusions : AM showed high relevance with the lipid metabolism related with the chemokine production and lipolysis pathways. This study could be a basis that AM has promising effects on obesity via network pharmacology analysis.1)
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KEYWORD
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Astragalus membranaceus Bunge, obesity, network pharmacology, potential efficacy, lipid metabolism
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